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Chronic anal fissure was assessed by clinical examination and a history of anal pain on defecation for longer than 2 months that did not resolve with stool softeners and simple anesthetic agents. Exclusion criteria were pregnancy, allergy to nifedipine or lidocaine, and complications warranting surgery. Study design and validity this was a prospective, randomized, double-blind study. Chronic anal fissure is the most common cause of anal pain associated with internal anal sphincter hypertonia. Reduction of hypertonocity is a special treatment for fissure healing. For this purpose chronic anal fissures were conventionally treated by anal dilatation or by lateral sphincterotomy. Methods anal manometry was performed on eight healthy volunteers and 15 patients with chronic anal fissure before and after oral administration of nifedipine 20 mg. Fissure healing was assessed over an 8-week period and pain scores were monitored. Other strengths of this anal fissure ointment can be made but 0. Other ingredients, such as lidocaine for pain, can also be added. Purpose nifedipine (administered orally or applied topically) has been effective for nonsurgical treatment of anal fissure. Glyceryl trinitrate for chemical sphincterotomy of anal fissure. analogous to the use of ntg intra-anal ointment, nifedipine ointment is also available for use in clinical trials. It is thought to have similar efficacy to ntg ointment but with fewer adverse. sitz baths, or hip baths, can promote healing of an anal fissure. By soaking the rectal area in a tub of warm water -- two or three times a day for 10 to 15 minutes -- you can clean the anus. Randomized clinical trial comparing oral nifedipine with lateral anal sphincterotomy and tailored sphincterotomy in the treatment of chronic anal fissure. Menteu015f bb, irku00f6ru00fccu00fc o, akin m, leventou011flu s, tatliciou011flu e. Comparison of botulinum toxin injection and lateral internal sphincterotomy for the treatment of chronic anal fissure. Active control for treatment of chronic anal fissure results of a prospective, randomized, double-blind study. When i asked about the nifedipine,the gastro doc told me id be better off with the 2nitro as long as i didnt have long term headaches,i was willing to try another cream too,wonder why these guys all have a different view on fissures,seems if some people have sucess witha certain cream.