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fibrin glue treatment of anal fistulas is simple, safe, and painless and the injections can be repeated to increase the healing rate without preventing from other eventual following surgical procedures. For these reasons in the past decade this technique became increasingly popular,. Backgroundaims surgical management of anal fistulas is associated with considerable morbidity, mainly related to anal sphincter injury. However, treatment with fibrin glue is a safe and simple method associated with less discomfort and complications. A prospective trial was conducted at our institute to evaluate the use of fibrin glue (tissucol, baxter, the netherlands) for simple and. Fibrin-glue treatment of anal fistulas is successful in up to 69 percent of patients if initial failures are retreated. This sphincter-saving technique is associated with minimal complications and no functional detriment. Request pdf on sep 1, 2003, p j shankar and others published fibrin glue and anal fistulas find, read and cite all the research you need on researchgate. Conclusions fibrin-glue treatment of anal fistulas is successful in up to 69 percent of patients if initial failures are retreated. fibrin sealant successfully closed the fistula tract in both patients. After a mean follow-up of 10 months, the overall success rate for fibrin glue closure of anal fistulas was 85. One patient had a recurrent cryptoglandular fistula after two previous fistulotomies and seton placement. Fibrin glue treatment is simple and repeatable failure does not compromise further treatment options and sphincter function is preserved. We aimed to compare the outcomes of patients with low and high anal fistulas randomly assigned to either fibrin glue or conventional treatment. Conclusions fibrin glue treatment for complex anal fistulas has a low success rate and most recrudescences occurred within three months. However, given the low morbidity and relative simplicity of the procedure, fibrin glue should still be considered as a first-line treatment for patients with complex anal fistulas. Our study on 14 high anal fistulas and 16 low anal fistulas, has analyzed the outcome after the instillation of fibrin glue in the anal tracts of the patients. A separate retrospective study of fibrin glue injection for complex anal fistulas in 39 patients, including cryptoglandular fistula, cd-related fistula, and ileal pouch-anal anastomotic fistula showed an initial closure in the majority of patients, but with a high risk of recurrence.