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Breakthrough treatment proves 90 success rate on painful anal fissures. Bristol-myers squibb has agreed to submit the complete study report (24 month follow-up) and data from the study, ca-180-015, a phase 2 multicenter study of dasatinib (bms-354825) in subjects with lymphoid blast phase chronic myeloid leukemia or philadelphia chromosome positive acute lymphoblastic leukemia resistant to high dose imatinib mesylate (gleevec) or who are intolerant of. License except as otherwise noted, this work is licensed under a creative commons attribution-noncommercial-share alike 4. For commercial use or customized versions, please contact biobyte solutions gmbh. Disclaimer the content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Anal fissure is a common anorectal disorder resulting in anal pain and bleeding. Fissures can either heal spontaneously and be classified as acute, or persist for 6 or more weeks and be classified. Evidence-based information on anal fissure from hundreds of trustworthy sources for health and social care. An anal fissure is a tear in the skin around the opening of the anus (the last part of the digestive tract that controls the removal of stools). It is associated with pain and bleeding during bowel movements. The condition is more common in young infants but it can happen at any age. Jennifer squiress 13 research works with 124 citations and 380 reads, including adenocarcinoma cells in effusion cytology as a diagnostic pitfall with potential impact on clinical management a. Anal fissures are common in infants and its rate decreases gradually with school-aged children and adults. In adults, it may be caused by constipation, the passing of large, hard stools, or by prolonged diarrhea. In older adults, anal fissures may be caused by decreased blood flow to the area. They mostly affect people aged 1540 years but can occur at any age. Anal fissures are most commonly caused by damage to the lining of the anus or anal canal, the last part of the large intestine. Most cases occur in people who have constipation, when a particularly hard or large poo tears the lining of the anal canal. Any one that suffers from anal fissures knows the pain, and the jarring to go to the bathroom. Breakthrough treatment proves 90 success rate on painful anal fissures.