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Anal cancer risk is 28-29 times higher in people with hiv infection, compared with the general population, with no difference between men and women, meta-analyses have shown. Anal cancer risk in people with hiv infection may be higher in current smokers, those with concurrent hpv infection, and those with more advanced hiv infection, a nested case-control study showed. Your risk of developing anal cancer increases as you get older. Around 25 out of 100 people (around 25) diagnosed with anal cancer each year in the uk are aged 75 and over. whether you or someone you love has cancer, knowing what to expect can help you cope. From basic information about cancer and its causes to in-depth information on specific cancer types including risk factors, early detection, diagnosis, and treatment options youll find it here. Anal intercourse men and women with a history of receptive anal intercourse, especially those younger than 30, have a higher risk of anal cancer. Some gynecologic cancers women with a history of cervical , vulvar or vaginal cancer, which are also are caused by hpv infection, have an increased anal cancer risk. Human papillomavirus (hpv) infection is the single most important risk factor which is associated with almost 85 to 95 of the cases of anal cancer. Although the incidence of hpv infection is very common, only a few cases progress to pre-cancerous anal lesions or invasive anal cancer. Anal cancer irs were 10 (95 ci 519), 6 (95 ci 311) and 3 (95 ci 24) for systemic lupus erythematosus, ulcerative colitis and crohns disease, respectively. In conclusion, a unifying anal cancer risk scale, based upon comprehensive metaanalysis, can improve prioritization and standardization in anal cancer preventionresearch initiatives, which are in their public health. if you have a high risk of anal cancer due to other factors, such as family history or age, make sure to discuss your concerns with your doctor. Anal infection with human papillomavirus resulting in genital warts is a major risk factor for the cancer. Immunocompromised patients, such as those with hiv disease, are prone to get anal cancer.