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Basaloid squamous cell carcinoma (scc) of the anus, previously called cloacogenic carcinoma, is a subtype of scc. There are very few data on the morphologic variation within basaloid scc of the anus, which may contribute to misdiagnosis. anal carcinomas account for nearly 2 of all colorectal malignancies. Squamous cell carcinomas are the most common type of tumors that arise within the anal canal and perianal region, the basaloid. who officially only recognizes squamous cell carcinoma basaloid variant has also been termed cloacogenic or transitional mucoepidermoid carcinoma may be used for tumors with prominent mucinous features, although the biology may be different (j gastroenterol 200136508). The pathology and results of treatment of 36 cases of basaloid carcinomas of the anal canal are described. This variant of squamous cell carcinoma of the anal region arises from the entodermal-ectodermal junctional zone of the anal canal at or above the dentate line. c basaloid anal carcinoma, metastatic to liver, consisting of large aggregates of basaloid tumor cells without apparent basement membrane material or squamous differentiation (h&e, 100). Basaloid scc of the anus is characterized by 4 major histologic patterns and is consistently hpv driven. Ab - basaloid squamous cell carcinoma (scc) of the anus, previously called cloacogenic carcinoma, is a subtype of scc. There are very few data on the morphologic variation within basaloid scc of the anus, which may contribute to misdiagnosis. squamous carcinoma, of varying levels of differentiation, involving the anal canal. Basaloid cloacogenic carcinoma of anal canal showing complete response to chemoradiotherapy a rare case with review of literature authors kaushal deep singh, farheen shahma senior resident, undergraduate student department of surgery, jawaharlal nehru medical college, aligarh muslim university, aligarh. Adenocarcinoma of the anal canal is a rare form of a rare tumor. It remains less prevalent than both basaloid and keratinizing tumors of the anal canal. Within the category of anal adenocarcinomas, uniformity in histology, biology, or etiology is lacking.